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Journal of US-China Medical Science 12 (2015) 12-19

doi: 10.17265/1548-6648/2015.01.002

Pilot Prospective Study on BDNF (Brain Derived Neurotrophic Factor) as a Predictive Biomarker of the Occurrence of PTSD (Post Traumatic Stress Disorder)
Etude pilote prospective: la neurotrophine (BDNF) comme marqueur predictif de la survenue de l'état de stress post traumatique (PTSD)]

Guanghua Yang1, 2, Bernard Vilamot3, Marc Passamar1, 3, Nouredine Sadeg1, Hafid Belhadj-Tahar1, 3

1. Department of Toxicology, AFPreMed, Toulouse 31000, France

2. Research Center for Translational Medicine, East Hospital, School of Medicine, Tongji University, Shanghai 200120, China

3. Department of Psychiatric Emergency (CAPS), Fondation Bon sauveur, Albi 81025, France

Abstract: The pilot study’s main objective was to assess the rate of serum BDNF (brain derived neurotrophic factor) and initial clinical course during three months of the matter submitted to a potentially traumatic event. In this study, 12 volunteers were recruited, 7 have been exposed to a traumatic event and 5 negative controls without psycho-trauma history. This study showed the following results: the rate of BDNF was significantly lower in the group of volunteers exposed to trauma compared with the control group: 6.20 ± 1.73 ng/mL for the group with trauma versus 21.79 ± 1.76 ng/mL for the control group with P < 0.001. The rate of serum BDNF is significantly collapsed in victims of physical aggression compared to those who have witnessed a traumatic event: 4.36 ± 0.37 ng/mL for assault group versus 6.94 ± 1.44 ng/mL control group event with P = 0.03. The level of BDNF is significantly inversely correlated with the intensity of the Peritraumatic distress (r = -0.75, P < 0.05). The rate of serum BDNF was significantly lower in the group with acute PTSD compared to group with no PTSD: 7.5 ± 0.9 ng/mL in the absence of PTSD (n = 4) versus 4.5 ± 0.49 ng/mL in the presence of PTSD (n = 3), P = 0.001.

Key words: Post traumatic stress, PTSD, brain-derived neurotrophic factor, BDNF, biomarker.

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