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Environnement et Santé

In Forensic Medicine and Anatomy Research, 2015, 3

Determination de l'exposition aux agents chimiques d'origine médicale et industrielle à Pekin par analyses des phanères (Ongles et cheveux) et du sang

Nos chercheurs du groupe "recherche et expertise toxicologique " en collaboration avec leurs collègues de l'Université de Shanghai, ont mis au point une méthode originale de dosage d'agents polluants incorporés dans la matrice d'ongle et de cheveux en comparaison avec le dosage sanguin.L'identification des produits retrouvés sur un échantillon de 40 personnes vivant à Beijing (Chine) a fait appel à la bibliothèque spectroscopique repertoriant les 10.000 molécules les plus retrouvées dans l'environnement des pays occidentaux industrialisés. Les résultats de cette étude mettent en évidence une exposition aux antibiotiques (Gentamycine, et tobarmycine), aux antidepresseurs (amitriptyline et dérivés); insecticides (carbamates); et aux phtalates.

Publié en 2015 dans SciRes.

In Forensic Medicine and Anatomy Research, 2015, 3

Determination of Exposure to Medical and Industrial Toxic Chemicals from Beijing by Human Hair, Nail and Blood Analysis

G. Yang*, D. Kechkeche**, H. Belhadj-Tahar***, N. Sadeg***

* School of Medicine, Tongji University, Shanghai, China .

** Departement of Chemistry, University of Pierre et Marie-Curie, Paris, France.

*** AFPreMed, Toxicology Research Group, Toulouse, France.

Published Online January 2015 in SciRes.


The aim of the present work was to investigate the exposure to the medical and industrial toxic chemicals. The research was carried out on hair, nail and blood samples in a panel of 40 healthy volunteers aged 7 to 77 with an average of 45 ± 19 years (18 women (45%) and 22 men (55%)).
All of these individuals had not received medication for at least 1 year, including antibiotics and psychotropic. This study was realized from July 2013 to March 2014 in Beijing, China. The method for an accurate and reliable screening of medical and an industrial toxic chemical was based on detection and assay by ultra-high performance liquid chromatography with UV detection type of diode arrays. Also more than 10,000 toxic molecules commonly found in western industrial countries were screened by coupling gas chromatography and mass spectrometry.
The main results indicate that the molecules analyzed are mainly antibiotic (Gentamycine and Tobramycine), antidepressant (Amitriptylin and its metabolites), narcotic (MDMA and Clonitazene), ingredient in cosmetics (Benzenediol and Benzoic acid), insecticide (Carbamate derivative), ketamine, chlorhexidine and phthalate derivatives. There are no detailed documented baseline data of the analysis of medical and Industrial toxic pollutants in hair, nail and blood samples in Beijing; however, this study should be completed on samples from other provinces of China. This study is the first of its kind. Therefore, further studies should be conducted in other cities and provinces of China to be compared with each other.


Pollutants, Hair, Nail, Blood, Toxicological Screening, Separative Method, Mass Spectrometry

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