Vieillissement et santé

Viamines et vieillissement

22/01/2012
AFPreMed apporte son soutien logistique aux travaux de recherche sur les vitamines chez le sujet âgé. Ces travaux sont menés par l’équipe de gériatrie de l’Hôpital de Pontoise et coordonnés par Dr SADEG qui met au point de nouvelles méthodes robustes et fiables de quantification de ces vitamines chez l’homme (1). Les vitamines C et D sont particulièrement ciblées en raison de leurs impacts importants sur le vieillissement et l’homéostasie du sujet âgé.
Les résultats de telles investigations concernant notamment la vitamine C sont en cours de publication.
1- Nouvelle méthode UHPLC-UV pour le dosage de la vitamine C plasmatique. KUANG PIAO Christelle Chen; SADEG Nouredine ; YOUCEF Mann. Annales de biologie clinique, 69 (2011) pp. 735-737.
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04/04/2013
Les résultats des travaux sur la vitamine C chez les sujets âgés seront bientôt publiés dans "The journal of Aging Research & Clinical Practice" sous le titre de : "VITAMIN C STATUS IN AN ELDERLY POPULATION HOSPITALIZED IN A GERIATRIC REHABILITATION UNIT".

Auteurs: C. Chen (1), O. Chermak (2), V. Has (2), H. Belhadj-Tahar (3), N. Sadeg (1)
1. Biology Laboratory, CH René Dubos F-95301 Pontoise, France; 2. Geriatric Department, CH René Dubos F-95301 Pontoise, France; 3. French Association for Medical Research Advancement (AFPreMed), 31100 Toulouse, France



Statut vitaminique C chez les personnes agées

08/06/2013
VITAMIN C STATUS IN AN ELDERLY POPULATION HOSPITALIZED IN A GERIATRIC REHABILITATION UNIT
C. Chen, O. Chermak, V. Has, H. Belhadj-Tahar, N. Sadeg
J Aging Res Clin Practice 2013;2(2):197-199
Abstract:
Background: Malnutrition and vitamin deficiencies are frequent in the elderly, especially after occurrence of deterioration in their health status. The aim of this study is to determine the vitamin C status as well and it relation with biological markers of inflammatory and nutritional status in patients hospitalized in a geriatric rehabilitation unit of a general hospital. Methods: This prospective study covers a population of 36 elderly admitted in the rehabilitation unit during one month. At admission, the blood concentrations of Vitamin C, CRP, Albumin and prealbumin were measured. Statistic studies were performed to assess the vitamin C status in this population and to determine the relation of vitamin C with the biological markers. Results: Most patients (94%) have biological criteria for malnutrition (serum albumin concentration <35g/L). Only four patients (11%) have levels of vitamin C over 5mg/L and these patients have also biological criteria for mild malnutrition. The AA levels observed in this study (the mean serum AA concentration in this study was 2.7 mg/L and the median is 1.95 mg/L) were compatible with vitamin C deficiency. Vitamin C deficiency was slightly correlated with biological criteria of inflammatory and malnutrition syndromes; with correlation index R2 of (vitamin C vs CRP) 0.20; R2 of (vitamin C vs albumin) = 0.38 and R2 of (vitamin C vs prealbumin) 0.32. Therefore CRP, albumin and prealbumin are not reliable predictive biological criteria for vitamin C deficiency. These results suggest that a systematic higher intake of vitamin C in the elderly may be particularly interesting after acute health status deterioration. Finally, screening for vitamin C status should be included in the assessment of the general health status of the elderly population.
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Journée thématique SFTCG

17/05/2019
A l'occasion de la journée thématique organisée par la Société Française de la Thérapie Cellulaire et Génique (SFTCG) à Paris , AFPREMED a présenté des travaux de recherche "Transfection efficiency and toxicology Assessment of Poly-L-lysins Dendrimer as non-viral vector "

Transfection efficiency and toxicology Assessment of Poly-L-lysins Dendrimer as non-viral vector

L DIEBOLD1, L GARRELLY2, J S REMY1, F GRANIER2, S MARIE2, G YANG2,3, H BELHADJ-TAHAR2,3

1- V-SAT, CNRS UMR 7199, Université de Strasbourg, Labex Medalis, Faculté de Pharmacie, 67400 Illkirch

2- Recherche & Développement, COLCOM, Cap Alpha, 34830 Clapiers

3- Association Française de Promotion de la Recherche Médicale (AFPREMED), 31100, Toulouse


Institut du cerveau et de la moelle (ICM) Hôpital Pitié Salpêtrière, Paris


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